Humoral immune responses against the immature laminin receptor protein show prognostic significance in patients with chronic lymphocytic leukemia.

@article{Friedrichs2008HumoralIR,
  title={Humoral immune responses against the immature laminin receptor protein show prognostic significance in patients with chronic lymphocytic leukemia.},
  author={Birte Friedrichs and Sandra Siegel and M. Kloess and Adel Barsoum and Joseph H. Coggin and James C Rohrer and Ilja Jakob and Markus Tiemann and Klaus Heidorn and Christoph Schulte and Dieter Kabelitz and Joerg Steinmann and Norbert Schmitz and Matthias Zeis},
  journal={Journal of immunology},
  year={2008},
  volume={180 9},
  pages={6374-84}
}
Chronic lymphocytic leukemia (CLL) is characterized by a highly variable clinical course. The role of an autologous tumor-specific immune control contributing to the variable length of survival in CLL is poorly understood. We investigated whether humoral immunity specific for the CLL-associated Ag oncofetal Ag/immature laminin receptor (OFA/iLR) has a prognostic value in CLL. Among sera of 67 untreated patients with CLL, 23 (34.3%) had detectable OFA/iLR Abs that were reactive for at least one… CONTINUE READING

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