Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis.

@article{Burkhardt2005HumoralIR,
  title={Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis.},
  author={Harald Burkhardt and Bettina Sehnert and Robert Bockermann and Ake Engstr{\"o}m and Jochen R. Kalden and Rikard Holmdahl},
  journal={European journal of immunology},
  year={2005},
  volume={35 5},
  pages={1643-52}
}
Collagen type II (CII) is a relevant joint-specific autoantigen in the pathogenesis of rheumatoid arthritis (RA). Whereas the reasons for the breakage of self tolerance to this major cartilage component are still enigmatic, T cell responses to glycosylated CII determinants in RA patients indicate that post-translational modifications play a role. Since the conversion of arginine into citrulline by peptidylarginine deiminases (PAD) in some non-joint-specific antigens such as filaggrin or fibrin… CONTINUE READING