Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes.

@article{Knip2002HumoralBA,
  title={Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes.},
  author={Mikael Knip and Marika Kukko and Petri Kulmala and Riitta K. Veijola and Olli Simell and Hans K. Akerblom and Jorma Ilonen},
  journal={American journal of medical genetics},
  year={2002},
  volume={115 1},
  pages={48-54}
}
We have studied the relationship between diabetes-associated autoantibodies and various HLA genotypes and alleles in patients with newly diagnosed type 1 diabetes, in non-diabetic siblings and in children representing the general population to test the hypothesis that specific HLA genes regulate the humoral immune response to various autoantigens. Among the newly diagnosed patients we observed that those carrying the DR4-DQB1*0302 haplotype had increased levels of insulin autoantibodies (IAA… CONTINUE READING

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