Humoral antibody to Mobiluncus curtisii, a potential serological marker for bacterial vaginosis

@article{Schwebke1996HumoralAT,
  title={Humoral antibody to Mobiluncus curtisii, a potential serological marker for bacterial vaginosis},
  author={Jane R. Schwebke and S C Morgan and Sharon L. Hillier},
  journal={Clinical Diagnostic Laboratory Immunology},
  year={1996},
  volume={3},
  pages={567 - 569}
}
While bacterial vaginosis (BV) is a polymicrobial syndrome, Mobiluncus spp. are the organisms most highly associated with this condition. It is possible that serum antibody to Mobiluncus spp. could be used as a serological marker for BV. Using immunofluorescence techniques, we studied the prevalence of antibody to M. curtisii among three cohorts-pregnant women, pediatric patients, and sexually inexperienced women. The prevalence of antibody in each of these three groups was 75, 6, and 0… 
Nucleic acid-based diagnosis of bacterial vaginosis and improved management using probiotic lactobacilli.
TLDR
Two studies show that nucleic acid-based methods are effective at identifying bacteria responsible for BV, and if such methods could be used to develop a commercially available, self-use kit, women would be much better placed to take control of their own health.
Prevalence of Mobiluncus spp Among Women With and Without Bacterial Vaginosis as Detected by Polymerase Chain Reaction
TLDR
Mobiluncus is more common in healthy women than previously suspected, with M mulieris as the predominant species, and the significant difference in the prevalence of M curtisii between women with bacterial vaginosis and uninfected women suggests that this species could be involved in the pathogenesis of bacterialvaginosis.
Diagnostic methods for bacterial vaginosis
  • J. Schwebke
  • Medicine
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 1999
Ž . Bacterial vaginosis BV is the most prevalent form of vaginitis. Although commonly associated with symptoms of odor and vaginal discharge, half of all women who meet the clinical criteria for the
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TLDR
A greater number of modifiable, behavioral-related risk factors predicted BV and the level of BV-related microorganisms among African-American compared to non-African-American pregnant women.
Hypothesis on the role of sub-clinical bacteria of the endometrium (bacteria endometrialis) in gynaecological and obstetric enigmas.
TLDR
The hypothesis that one common factor, bacteria endometrialis, could provide a plausible explanation for a variety of obstetric and gynaecological mysteries is particularly intriguing and there is sufficient evidence to justify further investigation.
Cervicovaginal Microbiota and Reproductive Health: The Virtue of Simplicity.
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Attempts to durably alter microbial composition in this compartment by promotion of Lactobacillus colonization with probiotics, modulation of vaginal pH, hormonal administration, and the eradication of pathogenic bacteria with antibiotics are described.
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TLDR
Results indicate that M.Curtisii is a more virulent species than M. mulieris, and agree with reports of M. curtisii found in postoperative and extragenital infections.
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TLDR
Differences appear to exist between immune mechanisms at cervicovaginal and uterine sites, as well as between immune responses induced by local and systemic immunizations, and the immunoglobulin classes of antibodies in uterine secretions were compared with the classes in CVM and serum.
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TLDR
It is concluded that nonspecific vaginitis is exceedingly common among women attending an inner-city clinic for sexually transmitted diseases and that most of the infected women are asymptomatic.
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TLDR
The characterization of these atypical isolates has important implications for future investigations in which serological methods are used for diagnosis, epidemiology, and determination of pathogenicity of Mobiluncus spp.
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TLDR
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TLDR
It is concluded that it is important to treat BV in patients with symptoms other than malodorous discharge, using metronidazole tablets 500 mg 3 times daily for 10 days versus placebo in the same regimen.
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TLDR
The standardized score facilitates future research concerning bacterial vaginosis because it provides gradations of the disturbance of vaginal flora which may be associated with different levels of risk for pregnancy complications.
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