Humoral and cellular immune parameters before and during immunosuppressive therapy of a patient with stiff-man syndrome and insulin dependent diabetes mellitus.

@article{Hummel1998HumoralAC,
  title={Humoral and cellular immune parameters before and during immunosuppressive therapy of a patient with stiff-man syndrome and insulin dependent diabetes mellitus.},
  author={Michael Hummel and Ivana Durinovic-Bell{\'o} and Ezio Bonifacio and Vito Lampasona and Josef Endl and Sabine Fessele and Florian Then Bergh and Claudia Trenkwalder and Eberhard Standl and Anette-G. Ziegler},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={1998},
  volume={65 2},
  pages={204-8}
}
OBJECTIVES Humoral and cellular immune reactivity are reported for two neuroendocrine autoantigens-glutamic acid decarboxylase (GAD) and the protein tyrosine phosphatase IA-2-in a patient with the autoimmune type of stiff-man syndrome and insulin dependent diabetes (IDDM). METHODS Antibodies and T cell proliferation against GAD and IA-2 and cytokine release of antigen stimulated T cells (IFN-gamma) were determined before and several times during immunosuppressive therapy with prednisolone… CONTINUE READING

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Immunobiology of stiff-person syndrome.

International reviews of immunology • 2008
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