Humoral and cell-mediated immune responses in humans to the NSP4 enterotoxin of rotavirus.

@article{Johansen1999HumoralAC,
  title={Humoral and cell-mediated immune responses in humans to the NSP4 enterotoxin of rotavirus.},
  author={Kari Johansen and Jorma Hinkula and F{\'e}lix Espinoza and Michael Levi and Chun Zeng and Ulla Rud{\'e}n and Timo Vesikari and Mark D Estes and Lennart Svensson},
  journal={Journal of medical virology},
  year={1999},
  volume={59 3},
  pages={369-77}
}
Rotavirus nonstructural protein NSP4 has recently been suggested to function as a viral enterotoxin and play a role in the pathophysiological mechanism whereby rotaviruses induce diarrhea. The ability of rotavirus NSP4 to stimulate a humoral immune response was examined in naturally infected children and adults, rotavirus vaccinated children, as well as a cellular immune response in adults. In this study, 10 of 10 naturally infected children and 9 of 10 rotavirus-vaccinated children showed a… CONTINUE READING

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