Humoral Immune Responses against the Immature Laminin Receptor Protein Show Prognostic Significance in Patients with Chronic Lymphocytic Leukemia12

@article{Friedrichs2008HumoralIR,
  title={Humoral Immune Responses against the Immature Laminin Receptor Protein Show Prognostic Significance in Patients with Chronic Lymphocytic Leukemia12},
  author={Birte Friedrichs and Sandra Siegel and M. Kloess and Adel Barsoum and Joseph H. Coggin and James Rohrer and Ilja Jakob and Markus Tiemann and Klaus Heidorn and Christoph Schulte and Dieter Kabelitz and Joerg Steinmann and Norbert Schmitz and Matthias Zeis},
  journal={The Journal of Immunology},
  year={2008},
  volume={180},
  pages={6374 - 6384}
}
  • Birte Friedrichs, Sandra Siegel, +11 authors Matthias Zeis
  • Published 2008
  • Medicine
  • The Journal of Immunology
  • Chronic lymphocytic leukemia (CLL) is characterized by a highly variable clinical course. The role of an autologous tumor-specific immune control contributing to the variable length of survival in CLL is poorly understood. We investigated whether humoral immunity specific for the CLL-associated Ag oncofetal Ag/immature laminin receptor (OFA/iLR) has a prognostic value in CLL. Among sera of 67 untreated patients with CLL, 23 (34.3%) had detectable OFA/iLR Abs that were reactive for at least one… CONTINUE READING

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