Humic acid induces apoptosis in human endothelial cells.

  title={Humic acid induces apoptosis in human endothelial cells.},
  author={Youcheng Hseu and Hurng-Wern Huang and S Wang and Hwei-Yan Chen and Fung-Jou Lu and Rung-Jiun Gau and Hsin-ling Yang},
  journal={Toxicology and applied pharmacology},
  volume={182 1},
Humic acid (HA) has been implicated as an etiologic factor in the vasculopathy of Blackfoot disease. In this study, the ability of HA to induce apoptosis was studied in cultured human umbilical vein endothelial cells. Treatment of endothelial cells with a variety of concentrations of HA (50-200 microg/ml) resulted in dose- and time-dependent sequences of… CONTINUE READING