Humanized telomeres and an attempt to express a functional human telomerase in yeast.

@article{Bah2004HumanizedTA,
  title={Humanized telomeres and an attempt to express a functional human telomerase in yeast.},
  author={Amadou A. Bah and François Bachand and Eveline Clair and Chantal Autexier and Raymund J Wellinger},
  journal={Nucleic acids research},
  year={2004},
  volume={32 6},
  pages={1917-27}
}
The maintenance of telomeric repeat DNA depends on an evolutionarily conserved reverse trans criptase called telomerase. In vitro, only the catalytic subunit and a telomerase-associated RNA are required for the synthesis of species-specific repeat DNA. In an attempt to establish a heterologous system for the study of the human telomerase enzyme, we expressed the two core components and predicted regulatory subunits in the yeast Saccharomyces cerevisiae. We show that adequate substrates for… CONTINUE READING

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