Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection.

@article{Libby2010HumanizedND,
  title={Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection.},
  author={Stephen James Libby and Michael A. Brehm and Dale L. Greiner and Leonard D Shultz and Michael McClelland and Kelly D. Smith and Brad T. Cookson and Joyce E. Karlinsey and Traci L. Kinkel and Steffen Porwollik and Roc{\'i}o Canals and Lisa A Cummings and Ferric C Fang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 35},
  pages={
          15589-94
        }
}
Salmonella enterica serovar Typhi, the cause of typhoid fever, is host-adapted to humans and unable to cause disease in mice. Here, we show that S. Typhi can replicate in vivo in nonobese diabetic (NOD)-scid IL2rgamma(null) mice engrafted with human hematopoietic stem cells (hu-SRC-SCID mice) to cause a lethal infection with pathological and inflammatory cytokine responses resembling human typhoid. In contrast, S. Typhi does not exhibit net replication or cause illness in nonengrafted or… CONTINUE READING
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