Humanized mice as a model to study human hematopoietic stem cell transplantation.

  title={Humanized mice as a model to study human hematopoietic stem cell transplantation.},
  author={Anne Nygaard Tanner and Stephen Eugene Taylor and Wittnee Decottignies and Bradford K Berges},
  journal={Stem cells and development},
  volume={23 1},
Hematopoietic stem cell (HSC) transplantation has the potential to treat a variety of human diseases, including genetic deficiencies, immune disorders, and to restore immunity following cancer treatment. However, there are several obstacles that prevent effective HSC transplantation in humans. These include finding a matched donor, having a sufficient number of cells for the transplant, and the potency of the cells in the transplant. Ethical issues prevent effective research in humans that… CONTINUE READING


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