Humanized hemato-lymphoid system mice.

@article{Theocharides2016HumanizedHS,
  title={Humanized hemato-lymphoid system mice.},
  author={Alexandre P A Theocharides and Anthony Rongvaux and Kristin Fritsch and Richard A Flavell and Markus G. Manz},
  journal={Haematologica},
  year={2016},
  volume={101 1},
  pages={
          5-19
        }
}
Over the last decades, incrementally improved xenograft mouse models, supporting the engraftment and development of a human hemato-lymphoid system, have been developed and now represent an important research tool in the field. The most significant contributions made by means of humanized mice are the identification of normal and leukemic hematopoietic stem cells, the characterization of the human hematopoietic hierarchy, and their use as preclinical therapy models for malignant hematopoietic… CONTINUE READING
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