Humanized VB22B minibody for human Mpl stimulates human megakaryopoiesis but does not enhance platelet aggregation.

@article{Matsuki2011HumanizedVM,
  title={Humanized VB22B minibody for human Mpl stimulates human megakaryopoiesis but does not enhance platelet aggregation.},
  author={Eri Matsuki and Yoshitaka Miyakawa and Akiko Yamane and Shinichiro Okamoto},
  journal={Experimental hematology},
  year={2011},
  volume={39 8},
  pages={829-36}
}
OBJECTIVE Thrombopoietin stimulates megakaryopoiesis and platelet production by binding to its receptor, Mpl, on hematopoietic progenitor cells. Previously, a murine VB22B minibody for Mpl was shown to stimulate megakaryocyte colony formation in vitro and increase the platelet count in cynomolgus monkeys. In this study, we directly compared the effects of a humanized VB22B minibody (huVB22B) with those of thrombopoietin and eltrombopag under the hypothesis that Mpl agonists might have different… CONTINUE READING