Humanized Rodent Models for Cancer Research

@article{Tian2020HumanizedRM,
  title={Humanized Rodent Models for Cancer Research},
  author={Huimin Tian and Yanan Lyu and Yong-Guang Yang and Zheng Hu},
  journal={Frontiers in Oncology},
  year={2020},
  volume={10}
}
As one of the most popular laboratory animal models, rodents have been playing crucial roles in mechanistic investigations of oncogenesis as well as anticancer drug or regimen discoveries. However, rodent tumors show different or no responses to therapies against human cancers, and thus, in recent years, increased attention has been given to mouse models with xenografted or spontaneous human cancer cells. By combining with the human immune system (HIS) mice, these models have become more… 

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