Humanized Mouse Models of Clinical Disease.

  title={Humanized Mouse Models of Clinical Disease.},
  author={Nicole C. Walsh and Laurie L. Kenney and Sonal Jangalwe and Ken-Edwin Aryee and Dale L. Greiner and Michael A. Brehm and Leonard D Shultz},
  journal={Annual review of pathology},
Immunodeficient mice engrafted with functional human cells and tissues, that is, humanized mice, have become increasingly important as small, preclinical animal models for the study of human diseases. Since the description of immunodeficient mice bearing mutations in the IL2 receptor common gamma chain (IL2rgnull) in the early 2000s, investigators have been able to engraft murine recipients with human hematopoietic stem cells that develop into functional human immune systems. These mice can… CONTINUE READING
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