Humanized Affinity-matured Monoclonal Antibody 8H9 Has Potent Antitumor Activity and Binds to FG Loop of Tumor Antigen B7-H3*

@article{Ahmed2015HumanizedAM,
  title={Humanized Affinity-matured Monoclonal Antibody 8H9 Has Potent Antitumor Activity and Binds to FG Loop of Tumor Antigen B7-H3*},
  author={Mahiuddin Ahmed and M. Cheng and Qi Zhao and Y. Goldgur and S. Cheal and Hongfen Guo and S. Larson and N. Cheung},
  journal={The Journal of Biological Chemistry},
  year={2015},
  volume={290},
  pages={30018 - 30029}
}
Background: B7-H3 is an immune inhibitory ligand and an antigen on many solid tumors. Results: Antibody 8H9 was humanized and affinity-matured, and its epitope was mapped to the FG loop of B7-H3. Conclusion: hu8H9 antibodies had potent antitumor activity and may modulate immune inhibitory properties of B7-H3. Significance: Antibodies were developed to target solid tumors and affect immune checkpoint blockade. B7-H3 (CD276) is both an inhibitory ligand for natural killer cells and T cells and a… Expand
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