Humanization of the mouse mammary gland by replacement of the luminal layer with genetically engineered preneoplastic human cells.

@article{Verbeke2014HumanizationOT,
  title={Humanization of the mouse mammary gland by replacement of the luminal layer with genetically engineered preneoplastic human cells.},
  author={Stephanie Verbeke and Evelyne Richard and Elodie Monceau and Xenia Schmidt and Beno{\^i}t Rousseau and Val{\'e}rie V{\'e}lasco and David Bernard and Herv{\'e} R. Bonnefoi and Gaetan MacGrogan and Richard D. Iggo},
  journal={Breast cancer research : BCR},
  year={2014},
  volume={16 6},
  pages={
          504
        }
}
INTRODUCTION The cell of origin for estrogen receptor α-positive (ERα+) breast cancer is probably a luminal stem cell in the terminal duct lobular units. To model these cells, we have used the murine myoepithelial layer in the mouse mammary ducts as a scaffold upon which to build a human luminal layer. To prevent squamous metaplasia, a common artifact in genetically-engineered breast cancer models, we sought to limit activation of the epidermal growth factor receptor (EGFR) during in vitro cell… CONTINUE READING
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