Humanization of an antibody recognizing a breast cancer specific epitope by CDR-grafting.

Abstract

BACKGROUND Muc1-H23 is a cell surface mucin that is expressed on normal breast luminal epithelial cells and over-expressed in most breast tumors. In addition, Muc-1 expressed by malignant cells is glycosylated differently than Muc-1 expressed by normal cells. This difference in glycosylation exposes a peptide epitope on malignant cells which is not exposed… (More)

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Cite this paper

@article{Fiorentini1997HumanizationOA, title={Humanization of an antibody recognizing a breast cancer specific epitope by CDR-grafting.}, author={Sandra Flavia Fiorentini and Ewa Matczak and R. C. Gallo and M S Reitz and Iafa Keydar and Bruce A. Watkins}, journal={Immunotechnology : an international journal of immunological engineering}, year={1997}, volume={3 1}, pages={45-59} }