Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130.

@article{Hashimoto2009HumaninIN,
  title={Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130.},
  author={Yuichi Hashimoto and Megumi Kurita and Sadakazu Aiso and Ikuo Nishimoto and Masaaki Matsuoka},
  journal={Molecular biology of the cell},
  year={2009},
  volume={20 12},
  pages={
          2864-73
        }
}
Humanin (HN) inhibits neuronal death induced by various Alzheimer's disease (AD)-related insults via an unknown receptor on cell membranes. Our earlier study indicated that the activation of STAT3 was essential for HN-induced neuroprotection, suggesting that the HN receptor may belong to the cytokine receptor family. In this study, a series of loss-of-function tests indicated that gp130, the common subunit of receptors belonging to the IL-6 receptor family, was essential for HN-induced… CONTINUE READING

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