Human vital amniotic membrane reduces adhesions in experimental intraperitoneal onlay mesh repair

  title={Human vital amniotic membrane reduces adhesions in experimental intraperitoneal onlay mesh repair},
  author={Alexander H. Petter-Puchner and R. H. Fortelny and Kathrin Mika and Simone Hennerbichler and Heinz Redl and Christian Gabriel},
  journal={Surgical Endoscopy},
BackgroundVarious antiadhesive coatings have been proposed for intraperitoneal onlay meshes (IPOM). However, adhesions, mesh infections, and impaired integration remain clinically relevant problems. In this experiment, human vital amniotic membrane (AM) was tested as antiadhesive mesh coating. Vital AM complies with clinical standards of product safety.MethodsIn this study, 24 rats were randomized to one control or two treatment groups (n = 8). An uncoated polypropylene mesh (Vitamesh) was… 

Dried human amniotic membrane as an antiadherent layer for intraperitoneal placing of polypropylene mesh in rats

Dried irradiated HAM does not prevent adhesion formation in intraabdominal peritoneal onlay PP mesh repair in rats, and any use of this biomaterial in adhesion prophylaxis must be undertaken respecting graft cell viability as much as possible.

Cell-coating affects tissue integration of synthetic and biologic meshes: comparative analysis of the onlay and underlay mesh positioning in rats

Overall, cell-coating of surgical meshes appears to a have a potential to improve mesh–tissue integration and is superior in the underlay position compared to onlay when uncoated.

Study of Intra-Abdominal Adhesion After Hernia Repair with Propylene Mesh in Comparison with Amniotic Membrane Attached with Propylene Mesh in an Animal Model

Although amniotic membrane has shown good effect in some previous studies, in this investigation it was not effective and increased the rate of infection in the case group, so more studies are recommended to have exact knowledge about effectiveness of amniotics in reducing postoperative intra-abdominal adhesion.

Effectiveness of polypropylene mesh coated bovine amniotic membrane with adhesion barrier (polyethylene glycol) in repair of abdominal wall hernias in rats

The combined use of BAM and 5% PEG 4000 was helpful to prevent the complications of PP mesh in the repair of experimental 2 × 2 cm of abdominal hernias in rats.

The Effects of Human Amniotic Membrane on Healing of Colonic Anastomosis in Dogs

HAM plays a positive role in healing of colonic anastomosis, and would lead to better histological outcomes compared to simple anastOMosis in dogs.

Effect of the Mode of Application of Cryopreserved Human Amniotic Membrane on Adhesion Formation after Abdomino-Pelvic Surgery in a Mouse Model

The use of HAM fragmented in LR solution is associated with a significantly lower incidence of postoperative adhesions in mice when compared to LR alone, HAM patch, or control.

Functionalized Strategies and Mechanisms of the Emerging Mesh for Abdominal Wall Repair and Regeneration.

Common functions of the mesh are subdivided into biomechanics-matched, macrophage-mediated, integration-enhanced, anti-infective and antiadhesive characteristics for a comprehensive overview of their effects with respect to host response and integration.

Amniotic membrane in oral and maxillofacial surgery

Preserved HAM is considered to be a safe and sufficient biomaterial in all fields of oral and maxillofacial wound healing and its postulated properties and common preservation techniques are reviewed.



Evaluation of Seprafilm and Amniotic Membrane as Adhesion Prophylaxis in Mesh Repair of Abdominal Wall Hernia in Rats

HAM and Seprafilm proved to be an effective antiadhesive barrier in PPM repair of abdominal wall hernia and were equally effective in preventing postoperative adhesions.

Adverse effects of porcine small intestine submucosa implants in experimental ventral hernia repair

Adverse effects were observed using SIS in an experimental model of ventral hernia and were not linked to fixation method or study design, suggesting its clinical use in hernia repair is necessary.

The use of composite meshes in laparoscopic repair of abdominal wall hernias: are there differences in biocompatibily?

On the whole, all composite meshes showed evidence of good biocompatibility, however, none of the coatings was completely able to prevent adhesions.

Evaluation of new prosthetic meshes for ventral hernia repair

The authors recommend the use of Parietex Composite and Sepramesh for hernia repair in which direct contact with the abdominal viscera cannot be avoided, and combine minimal adhesion formation with maximum mesh incorporation and tensile strength.

Human Amniotic Membrane Transplantation With Fibrin Glue in Management of Primary Pterygia: A New Tuck-in Technique

Use of fibrin glue for attaching human amniotic membrane graft in primary pterygium surgery is effective, it not only reduces the surgical time but also minimizes postoperative discomfort and complications.

Management of infections of polytetrafluoroethylene-based mesh.

Although mesh with extensive infection could not be salvaged, limited mesh infections could be managed successfully with percutaneous or open drainage and prolonged antibiotic courses.