Human visceral afferent recordings: preliminary report.

  title={Human visceral afferent recordings: preliminary report.},
  author={Madusha Peiris and David C Bulmer and Mark D Baker and George Boundouki and Sidhartha Sinha and Anthony Hobson and Kevin Ck Lee and Q. Aziz and Charles Henry Knowles},
  volume={60 2},
BACKGROUND Conditions characterised by chronic visceral pain represent a significant healthcare burden with limited treatment options. While animal models have provided insights into potential mechanisms of visceral nociception and identified candidate drug targets, these have not translated into successful treatments in humans. OBJECTIVE To develop an in vitro afferent nerve preparation using surgically excised freshly isolated human colon and vermiform appendix-mesentery tissues. METHODS… CONTINUE READING


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Publications referenced by this paper.
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