Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate?

@article{Dorne2002HumanVI,
  title={Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate?},
  author={J L C M Dorne and Kimp Walton and Wout Slob and Andrew G. Renwick},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2002},
  volume={40 11},
  pages={1633-56}
}
Human variability in the kinetics of CYP2D6 substrates has been quantified using a database of compounds metabolised extensively (>60%) by this polymorphic enzyme. Published pharmacokinetic studies (after oral and intravenous dosing) in non-phenotyped healthy adults, and phenotyped extensive (EMs), intermediate or slow-extensive (SEMs) and poor metabolisers (PMs) have been analysed using data for parameters that relate primarily to chronic exposure (metabolic and total clearances, area under… CONTINUE READING

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