Human uveal melanoma cells produce macrophage migration-inhibitory factor to prevent lysis by NK cells.

@article{Repp2000HumanUM,
  title={Human uveal melanoma cells produce macrophage migration-inhibitory factor to prevent lysis by NK cells.},
  author={Amanda C. Repp and Elizabeth S. Mayhew and Sherine Apte and Jerry Y. Niederkorn},
  journal={Journal of immunology},
  year={2000},
  volume={165 2},
  pages={710-5}
}
Human uveal melanoma arises in an immune privileged ocular environment in which both adaptive and innate immune effector mechanisms are suppressed. Uveal melanoma is the most common intraocular tumor in adults and is derived from tissues in the eye that produce macrophage migration-inhibitory factor (MIF), a cytokine that has recently been demonstrated to produce immediate inhibition of NK cell-mediated lytic activity. Although NK cell-mediated lysis of uveal melanomas is inhibited in the eye… CONTINUE READING
44 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 44 extracted citations

Similar Papers

Loading similar papers…