Human uterine arterial relaxation induced by nitroxidergic nerve stimulation.

@article{Toda1994HumanUA,
  title={Human uterine arterial relaxation induced by nitroxidergic nerve stimulation.},
  author={Noboru Toda and Toshifumi Kimura and Kenji Yoshida and David S. Bredt and Solomon H Snyder and Yuichi Yoshida and Tomio Okamura},
  journal={The American journal of physiology},
  year={1994},
  volume={266 4 Pt 2},
  pages={H1446-50}
}
Uterine arterial strips obtained from humans responded to nicotine with a contraction, which was abolished by prazosin. In the arteries treated with the alpha 1-receptor antagonist and partially contracted with serotonin, nicotine produced a relaxation that was not influenced by treatment with atropine or timolol and endothelium denudation but was abolished by hexamethonium, oxyhemoglobin, and NG-nitro-L-arginine (L-NNA). The inhibitory effect of L-NNA was reversed by L- but not D-arginine… CONTINUE READING