Human urotensin II is a novel activator of NADPH oxidase in human pulmonary artery smooth muscle cells.

@article{Djordjevic2005HumanUI,
  title={Human urotensin II is a novel activator of NADPH oxidase in human pulmonary artery smooth muscle cells.},
  author={Talija Djordjevic and Rachida Siham Belaiba and Steve Bonello and Josef Pfeilschifter and John T. Hess and Agnes G{\"o}rlach},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2005},
  volume={25 3},
  pages={519-25}
}
BACKGROUND Human urotensin II (hU-II) is a potent vasoactive peptide possibly involved in pulmonary hypertension. Because the signaling mechanisms activated by this peptide in the pulmonary vasculature are largely unknown, we investigated the role of hU-II in the activation of NADPH oxidase and the control of redox-sensitive kinase pathways, expression of plasminogen activator inhibitor-1 (PAI-1), and proliferation in pulmonary artery smooth muscle cells (PASMCs). METHODS AND RESULTS hU-II… CONTINUE READING