Human urotensin-II as a novel cardiovascular target: 'heart' of the matter or simply a fishy 'tail'?

@article{Douglas2003HumanUA,
  title={Human urotensin-II as a novel cardiovascular target: 'heart' of the matter or simply a fishy 'tail'?},
  author={Stephen Andrew Douglas},
  journal={Current opinion in pharmacology},
  year={2003},
  volume={3 2},
  pages={
          159-67
        }
}
Urotensin-II (U-II), originally identified as a fish neuropeptide, exerts a broad spectrum of biological actions in mammals: responses that influence cardiorenal, pulmonary (bronchoconstriction), central nervous system (locomotion) and endocrine (thyroid-stimulating hormone, prolactin and insulin secretion) function. Because the U-II isopeptide family is highly conserved across species, both amongst invertebrates and vertebrates, it has been inferred that U-II and its G-protein-coupled receptor… CONTINUE READING
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