Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4.

@article{Cassard1990HumanUP,
  title={Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4.},
  author={A M Cassard and Fr{\'e}d{\'e}ric Bouillaud and Marie Genevi{\`e}ve Mattei and E Hentz and Serge Raimbault and Monique Thomas and Daniel Ricquier},
  journal={Journal of cellular biochemistry},
  year={1990},
  volume={43 3},
  pages={
          255-64
        }
}
The uncoupling protein (UCP) gene encodes a unique mammalian mitochondrial proton carrier that induces heat production in brown adipocytes. Human UCP gene was isolated and its organization analyzed. A comparison was made with rat UCP gene. Human UCP gene spans 13 Kb and contains a transcribed region that covers 9 Kb of the human genome. All of the exons were also sequenced except the extreme end of the 3' untranslated region. Two Kb DNA upstream the TATA box were also sequenced. This region… CONTINUE READING

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