Human umbilical vein endothelium-derived cells retain potential to differentiate into smooth muscle-like cells.

@article{Ishisaki2003HumanUV,
  title={Human umbilical vein endothelium-derived cells retain potential to differentiate into smooth muscle-like cells.},
  author={Akira Ishisaki and Hisaki Hayashi and Ai-jun Li and Toru Imamura},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 2},
  pages={1303-9}
}
Mouse embryonic stem-derived cells were recently shown to differentiate into endothelial and smooth muscle cells. In the present study, we investigated whether human umbilical vein endothelium-derived cells retain the potential to differentiate into smooth muscle cells. Examination of biochemical markers, including basic calponin, SM22alpha, prostaglandin E synthase, von Willebrand factor, and PECAM-1, as well as cell contractility, showed that whereas endothelium-derived cells cultured with… CONTINUE READING