Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor.

@article{Sjstrm2001HumanUV,
  title={Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor.},
  author={Mattias Sj{\"o}str{\"o}m and P J Jakobsson and Mich{\`e}le Heimburger and Jan Palmblad and Jesper Z. Haeggstr{\"o}m},
  journal={European journal of biochemistry},
  year={2001},
  volume={268 9},
  pages={2578-86}
}
Certain immunocompetent myeloid cells, such as eosinophils, basophils and mast cells, have a large capacity to synthesize the potent proinflammatory and spasmogenic mediator leukotriene (LT) C4 via a specific microsomal glutathione S-transferase (MGST) termed LTC4 synthase (LTC4S). Here, we report that MGST2, a distant homologue of LTC4S, is abundantly expressed in Human umbilical vein endothelial cells (HUVEC) and converts LTA4 into a single product, LTC4. Thus, using Northern blot, RT-PCR… CONTINUE READING

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