Human umbilical cord plasma proteins revitalize hippocampal function in aged mice.

@article{Castellano2017HumanUC,
  title={Human umbilical cord plasma proteins revitalize hippocampal function in aged mice.},
  author={Joseph M Castellano and Kira Irving Mosher and Rachelle J. Abbey and Alisha A. McBride and Michelle L. James and Daniela Berdnik and Jadon C Shen and Bende Zou and Xinmin Simon Xie and Martha Tingle and Izumi V. Hinkson and Martin S. Angst and Tony Wyss-Coray},
  journal={Nature},
  year={2017},
  volume={544 7651},
  pages={488-492}
}
Ageing drives changes in neuronal and cognitive function, the decline of which is a major feature of many neurological disorders. The hippocampus, a brain region subserving roles of spatial and episodic memory and learning, is sensitive to the detrimental effects of ageing at morphological and molecular levels. With advancing age, synapses in various hippocampal subfields exhibit impaired long-term potentiation, an electrophysiological correlate of learning and memory. At the molecular level… CONTINUE READING
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