Human umbilical cord matrix stem cells efficiently rescue acute liver failure through paracrine effects rather than hepatic differentiation.

@article{Zhang2012HumanUC,
  title={Human umbilical cord matrix stem cells efficiently rescue acute liver failure through paracrine effects rather than hepatic differentiation.},
  author={Shichang Zhang and Li Chen and Tao Liu and Bo Zhang and Dedong Xiang and Zhengguo Wang and Yingjie Wang},
  journal={Tissue engineering. Part A},
  year={2012},
  volume={18 13-14},
  pages={
          1352-64
        }
}
There is increasing evidence that mesenchymal stem cells (MSCs) derived from different tissues could act as an alternative source of mature hepatocytes for treatment of acute liver failure (ALF). Human umbilical cord matrix stem cells (hUCMSCs) represent a novel source of MSCs. We examined the therapeutic potential and the different mechanisms of hUCMSCs by their transplantation into nonobese diabetic severe combined-immunodeficient (NOD-SCID) mice with carbon tetrachloride (CCl(4))-induced ALF… CONTINUE READING
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