Human umbilical cord-derived mesenchymal stem cells downregulate inflammatory responses by shifting the Treg/Th17 profile in experimental colitis.

@article{Li2013HumanUC,
  title={Human umbilical cord-derived mesenchymal stem cells downregulate inflammatory responses by shifting the Treg/Th17 profile in experimental colitis.},
  author={Liren Li and Suzhe Liu and Yue Xu and Aixian Zhang and Jinxia Jiang and Wei Tan and Jing Fu Xing and Guijuan Feng and Hong Liu and Fangxin Huo and Qiyun Tang and Zhifeng Gu},
  journal={Pharmacology},
  year={2013},
  volume={92 5-6},
  pages={257-64}
}
BACKGROUND/AIMS The aim of this study was to evaluate the effect and mechanisms of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) on immune responses in murine colitis. METHODS Mice with dextran sulfate sodium (DSS)-induced colitis were injected intraperitoneally with hUC-MSCs or human bone marrow-derived MSCs. The cytokine levels from lamina propria mononuclear cells (LPMCs) and colon tissue were measured using ELISA. Treg and Th17 cells were analyzed using flow cytometry… CONTINUE READING