Human umbilical cord Wharton's jelly-derived mesenchymal stem cells differentiate into a Schwann-cell phenotype and promote neurite outgrowth in vitro.

@article{Peng2011HumanUC,
  title={Human umbilical cord Wharton's jelly-derived mesenchymal stem cells differentiate into a Schwann-cell phenotype and promote neurite outgrowth in vitro.},
  author={Jiang Peng and Yu Wang and Li Zhang and Bin Zhao and Zhe Zhao and Jifeng Chen and Quanyi Guo and Shuyun Liu and Xiang Sui and Wenjing Xu and Shibi Lu},
  journal={Brain research bulletin},
  year={2011},
  volume={84 3},
  pages={235-43}
}
Cell-based therapy has achieved promising functional recovery for peripheral nerve repair. Although Schwann cells (SCs) and bone marrow derived mesenchymal stromal cells (BM-MSCs) are the main cell source for nerve tissue engineering, the clinical application is limited because of donor site morbidity, the invasive procedure, and the decreased number of SCs and BM-MSCs. Wharton's jelly-derived mesenchymal stem cells (WJMSCs) could be a promising cell source for nerve tissue engineering because… CONTINUE READING
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