Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity.

  title={Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity.},
  author={Yoshiyuki Minegishi and Masako Saito and Tomohiro Morio and Ken Watanabe and Kazunaga Agematsu and Shigeru Tsuchiya and Hidetoshi Takada and Toshiro Hara and Nobuaki Kawamura and Tadashi Ariga and Hideo Kaneko and Naomi Kondo and Ikuya Tsuge and Akihiro Yachie and Yukio Sakiyama and Tsutomu Iwata and Fumio Bessho and Tsutomu Ohishi and Kosuke Joh and Kohsuke Imai and Kazuhiro Kogawa and Miwa Shinohara and Mikiya Fujieda and Hiroshi Wakiguchi and Srdjan S Pasi{\'c} and Mario Abinun and Hans D. Ochs and Eleonore D Renner and Annette Jansson and Bernd H. Belohradsky and Ahmet Metin and Norio Shimizu and Shuki Mizutani and Toshio Miyawaki and Shigeaki Nonoyama and Hajime Karasuyama},
  volume={25 5},
Tyrosine kinase 2 (Tyk2) is a nonreceptor tyrosine kinase that belongs to the Janus kinase (Jak) family. Here we identified a homozygous Tyk2 mutation in a patient who had been clinically diagnosed with hyper-IgE syndrome. This patient showed unusual susceptibility to various microorganisms including virus, fungi, and mycobacteria and suffered from atopic dermatitis with elevated serum IgE. The patient's cells displayed defects in multiple cytokine signaling pathways including those for type I… CONTINUE READING
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