Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution.

@article{Dufort2001HumanT1,
  title={Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution.},
  author={Isabelle Dufort and Fernand Labrie and Van Luu-The},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2001},
  volume={86 2},
  pages={841-6}
}
3 alpha-Hydroxysteroid dehydrogenases (3 alpha-HSDs) catalyze the conversion of 3-ketosteroids to 3 alpha-hydroxy compounds. The best known 3 alpha-HSD activity is the transformation of the most potent natural androgen, dihydrotestosterone, into 5 alpha-androstan-3 alpha,17 beta-diol (3 alpha-diol), a compound having much lower activity. Previous reports show that 3 alpha-HSDs are involved in the metabolism of glucocorticoids, progestins, prostaglandins, bile acid precursors, and xenobiotics. 3… CONTINUE READING
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