Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

@article{Bernink2013HumanT1,
  title={Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues},
  author={J. Bernink and C. Peters and Marius Munneke and A. A. Velde and S. Meijer and K. Weijer and Hulda S Hreggvidsd{\'o}ttir and S. Heinsbroek and N. Legrand and C. Buskens and W. A. Bemelman and J. Mj{\"o}sberg and H. Spits},
  journal={Nature Immunology},
  year={2013},
  volume={14},
  pages={221-229}
}
  • J. Bernink, C. Peters, +10 authors H. Spits
  • Published 2013
  • Biology, Medicine
  • Nature Immunology
  • Innate lymphoid cells (ILCs) are effectors of innate immunity and regulators of tissue modeling. Recently identified ILC populations have a cytokine expression pattern that resembles that of the helper T cell subsets TH2, TH17 and TH22. Here we describe a distinct ILC subset similar to TH1 cells, which we call 'ILC1'. ILC1 cells expressed the transcription factor T-bet and responded to interleukin 12 (IL-12) by producing interferon-γ (IFN-γ). ILC1 cells were distinct from natural killer (NK… CONTINUE READING
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