Human tumour cathepsin B. Comparison with normal liver cathepsin B.

  title={Human tumour cathepsin B. Comparison with normal liver cathepsin B.},
  author={Kamiar Moin and Nancy A. Day and Mansoureh Sameni and Sadiq Hasnain and Tomoko Hirama and Bonnie F Sloane},
  journal={The Biochemical journal},
  volume={285 ( Pt 2)},
Cathepsin B was purified from normal human liver and several human tumour tissues and partially characterized. Three forms of cathepsin B, with molecular masses of 25 kDa, 26 kDa (the two appearing as a doublet) and 30 kDa, were detected in SDS/polyacrylamide gels. The 25-26 kDa doublet was associated with the fractions from tumours and normal liver containing the highest cathepsin B activity. Cathepsin B from both sources showed similar pH optima. Both normal liver and tumour cathepsin B… CONTINUE READING


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Aspects of the Biochemistry and Molecular Biology of Tumors (Pretlow

  • B. F. Sloane, K. Momn, T. T. Lah
  • 1992
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