Human tumor necrosis factor alpha influences rainbow trout Oncorhynchus mykiss leucocyte responses.

@article{Hardie1994HumanTN,
  title={Human tumor necrosis factor alpha influences rainbow trout Oncorhynchus mykiss leucocyte responses.},
  author={Laura J. Hardie and Laurie Chappell and Christopher J Secombes},
  journal={Veterinary immunology and immunopathology},
  year={1994},
  volume={40 1},
  pages={
          73-84
        }
}
Human recombinant tumor necrosis factor alpha (rTNF alpha) and rainbow trout macrophage activating factor (postulated gamma-interferon (gamma-IFN) analogue) synergised to elevate the respiratory burst activity of trout macrophages. This elevated response may parallel phenomena described in mammals where TNF alpha and gamma-IFN commonly synergise. Human rTNF alpha also synergised with mitogenic stimuli to heighten proliferation responses of trout head kidney leucocytes. These data are indicative… CONTINUE READING
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