Human tumor-derived heat shock protein 96 mediates in vitro activation and in vivo expansion of melanoma- and colon carcinoma-specific T cells.

@article{Rivoltini2003HumanTH,
  title={Human tumor-derived heat shock protein 96 mediates in vitro activation and in vivo expansion of melanoma- and colon carcinoma-specific T cells.},
  author={Licia Rivoltini and Chiara Castelli and Matteo Giovanni Carrabba and Vincenzo Mazzaferro and Lorenzo Pilla and Veronica Huber and Jorgelina Coppa and Gianfrancesco Gallino and Carmen Scheibenbogen and Paola Squarcina and Agata Cova and Roberto Camerini and Jonathan J. Lewis and Pramod K. Srivastava and Giorgio Parmiani},
  journal={Journal of immunology},
  year={2003},
  volume={171 7},
  pages={3467-74}
}
Heat shock proteins (hsp) 96 play an essential role in protein metabolism and exert stimulatory activities on innate and adaptive immunity. Vaccination with tumor-derived hsp96 induces CD8(+) T cell-mediated tumor regressions in different animal models. In this study, we show that hsp96 purified from human melanoma or colon carcinoma activate tumor- and Ag-specific T cells in vitro and expand them in vivo. HLA-A*0201-restricted CD8(+) T cells recognizing Ags expressed in human melanoma… CONTINUE READING

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