Human tumor antigens recognized by T lymphocytes

  title={Human tumor antigens recognized by T lymphocytes},
  author={T. Boon and Pierre van der Bruggen},
  journal={The Journal of Experimental Medicine},
  pages={725 - 729}
W e have come a long way since the identification of the first human tumor antigen recognized by autologous CTL. This report provides a brief appraisal of these antigens and their potential for cancer immunotherapy. Our comments will be restricted to nonviral antigens. The initial work carried out on mouse tumors revealed two possible mechanisms for generating new antigens that might be suflficiendy tumor-specific to be of relevance to immunotherapy. The first mechanism involved a point… CONTINUE READING
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