Human triallelic sites: evidence for a new mutational mechanism?

@article{Hodgkinson2010HumanTS,
  title={Human triallelic sites: evidence for a new mutational mechanism?},
  author={Alan Hodgkinson and Adam Eyre-Walker},
  journal={Genetics},
  year={2010},
  volume={184 1},
  pages={233-41}
}
Most SNPs in the human genome are biallelic; however, there are some sites that are triallelic. We show here that there are approximately twice as many triallelic sites as we would expect by chance. This excess does not appear to be caused by natural selection or mutational hotspots. Instead we propose that a new mutation can induce another mutation either within the same individual or subsequently during recombination. We provide evidence for this model by showing that the rarer two alleles at… CONTINUE READING

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