Human transcriptome analysis reveals a potential role for active transport in the metabolism of Pseudomonas aeruginosa autoinducers.

@article{Bryan2010HumanTA,
  title={Human transcriptome analysis reveals a potential role for active transport in the metabolism of Pseudomonas aeruginosa autoinducers.},
  author={Amanda C. Bryan and Chase Watters and Lars Koenig and Eunseog Youn and Aaron Olmos and Guigen Li and Simon C. Williams and Kendra P. Rumbaugh},
  journal={Microbes and infection},
  year={2010},
  volume={12 12-13},
  pages={1042-50}
}
The opportunistic pathogen Pseudomonas aeruginosa employs acyl homoserine lactones (AHL) as signaling compounds to regulate virulence gene expression via quorum sensing. The AHL N-3-oxo-dodecanoyl-l-homoserine lactone (3OC(12)-HSL) also induces mammalian cell responses, including apoptosis and immune modulation. In certain cell types the apoptotic effects of 3OC(12)-HSL are mediated via a calcium-dependent signaling pathway, while some pro-inflammatory effects involve intracellular… CONTINUE READING

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