Human transcription factors contain a high fraction of intrinsically disordered regions essential for transcriptional regulation.

Abstract

Human transcriptional regulation factors, such as activators, repressors, and enhancer-binding factors are quite different from their prokaryotic counterparts in two respects: the average sequence in human is more than twice as long as that in prokaryotes, while the fraction of sequence aligned to domains of known structure is 31% in human transcription… (More)

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@article{Minezaki2006HumanTF, title={Human transcription factors contain a high fraction of intrinsically disordered regions essential for transcriptional regulation.}, author={Yoshiaki Minezaki and Keiichi Homma and Akira R. Kinjo and Ken Nishikawa}, journal={Journal of molecular biology}, year={2006}, volume={359 4}, pages={1137-49} }