Human topoisomerase I poisoning by protoberberines: potential roles for both drug-DNA and drug-enzyme interactions.

Abstract

Protoberberines represent a structural class of organic cations that induce topoisomerase I-mediated DNA cleavage, a behavior termed topoisomerase I poisoning. We have employed a broad range of biophysical, biochemical, and computer modeling techniques to characterize and cross-correlate the DNA-binding and topoisomerase poisoning properties of four… (More)

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@article{Li2000HumanTI, title={Human topoisomerase I poisoning by protoberberines: potential roles for both drug-DNA and drug-enzyme interactions.}, author={T. K. Li and Eleanor Bathory and Emma Lavoie and Aravind Srinivasan and Wayne Olson and Ronald R. Sauers and L. F. Liu and Daniel S. Pilch}, journal={Biochemistry}, year={2000}, volume={39 24}, pages={7107-16} }