Human tissue-type plasminogen activator gene located near chromosomal breakpoint in myeloproliferative disorder.

@article{YangFeng1986HumanTP,
  title={Human tissue-type plasminogen activator gene located near chromosomal breakpoint in myeloproliferative disorder.},
  author={Teresa L. Yang-Feng and Ghislain Opdenakker and G. Volckaert and Uta Francke},
  journal={American journal of human genetics},
  year={1986},
  volume={39 1},
  pages={79-87}
}
Plasminogen activators (PA) convert the inactive proenzyme plasminogen into plasmin, which is involved in the process of fibrinolysis, tissue remodeling, and cell migration. There are two distinct forms of PA: urokinase (u-PA) and tissue-type plasminogen activator (t-PA). t-PA has higher affinity for fibrin and is the main form involved in thrombolysis. By in situ chromosomal hybridization and Southern blot analysis of somatic cell hybrid DNA, we have assigned the human t-PA gene to chromosome… CONTINUE READING

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