Human tissue-specific microenvironment: an essential requirement for mouse models of breast cancer.

@article{Xia2010HumanTM,
  title={Human tissue-specific microenvironment: an essential requirement for mouse models of breast cancer.},
  author={Tiansong Xia and Jue Wang and Hong Yin and Qiang Ding and Yi-fen Zhang and Hai-Wei Yang and Xiao-an Liu and Min Dong and Qing Du and Li-jun Ling and Xiao-ming Zha and Wei Fu and Shui Wang},
  journal={Oncology reports},
  year={2010},
  volume={24 1},
  pages={203-11}
}
An ideal mouse model should closely mimic a clinical situation. However, for most models available, this is not the case since clinical trials frequently fail to reproduce the highly encouraging therapeutic results obtained from pre-clinical studies performed using mouse models. In this study, in the process of extending the application of our previously established breast tissue-derived orthotopic and metastatic (BOM) model, the human breast cancer cell line MDA-MB-231 failed to exhibit any… CONTINUE READING

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