Human thymocyte development in mouse organ cultures.


A novel system to study human thymocyte development is described in which embryonic mouse thymic rudiments are seeded with human precursor cells in vitro. In these cultures human thymocytes proliferate extensively (greater than 20-fold increase in cell number) and mature, as evidenced by the accumulation of double and single positive (CD4+ and/or CD8… (More)


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@article{Fisher1990HumanTD, title={Human thymocyte development in mouse organ cultures.}, author={Alain Fisher and Laura S Larsson and Lindsey K. Goff and Deborah E. Restall and Lisa C. Happerfield and M. Merkenschlager}, journal={International immunology}, year={1990}, volume={2 6}, pages={571-8} }