Human thymocyte development in mouse organ cultures.

  title={Human thymocyte development in mouse organ cultures.},
  author={Amanda G Fisher and Lars-inge Larsson and L. Kerkerian-Le Goff and Deborah E. Restall and Lisa C. Happerfield and Matthias Merkenschlager},
  journal={International immunology},
  volume={2 6},
A novel system to study human thymocyte development is described in which embryonic mouse thymic rudiments are seeded with human precursor cells in vitro. In these cultures human thymocytes proliferate extensively (greater than 20-fold increase in cell number) and mature, as evidenced by the accumulation of double and single positive (CD4+ and/or CD8+) cells. Data presented here suggest that the survival and ordered development of the mature human thymocytes in chimeric thymuses is dependent on… CONTINUE READING
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