Human thymine-DNA glycosylase maps at chromosome 12q22-q24.1: a region of high loss of heterozygosity in gastric cancer.

@article{Schmutte1997HumanTG,
  title={Human thymine-DNA glycosylase maps at chromosome 12q22-q24.1: a region of high loss of heterozygosity in gastric cancer.},
  author={Christoph Schmutte and Raffaele Baffa and Luisa M. Veronese and Yoshiki Murakumo and Richard Fishel},
  journal={Cancer research},
  year={1997},
  volume={57 14},
  pages={3010-5}
}
Spontaneous hydrolytic deamination of 5-methylcytosine leads to T:G mismatches in double-stranded DNA and comprises a major threat for the integrity of both the DNA primary sequence as well as the epigenetic information stored in the DNA methylation pattern. Failure of the cellular DNA repair machinery to recognize and repair such mismatched nucleotides can lead to a mutator phenotype and subsequent carcinogenesis. A thymine-DNA glycosylase (TDG) has been described that initiates T:G mismatch… CONTINUE READING

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