Human thiopurine methyltransferase activity varies with red blood cell age.

@article{Lennard2001HumanTM,
  title={Human thiopurine methyltransferase activity varies with red blood cell age.},
  author={Lynne Lennard and Thean S. Chew and John S. Lilleyman},
  journal={British journal of clinical pharmacology},
  year={2001},
  volume={52 5},
  pages={539-46}
}
AIMS Inherited differences in thiopurine methyltransferase (TPMT) activity are an important factor in the wide interindividual variations observed in the clinical response to thiopurine chemotherapy. The aim of this study was to establish a population range for red blood cell (RBC) TPMT activity in children with acute lymphoblastic leukaemia (ALL) at disease diagnosis. An additional aim was to investigate factors that can influence TPMT activity within the RBC. METHODS Blood samples were… CONTINUE READING

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